Therapy for Relapsed Disease  A number of chemotherapy combinations have demonstrated antitumor activity. These include:
• MINE (mesna + ifosfamide + Novantrone + etoposide [VP-16])
• CHAD/DHAP (cisplatin + cytosine arabinoside [Ara-C] + dexamethasone)
• ESHAP (etoposide [VP-16] + Solumedrol + cytosine arabinoside [Ara-C] + cisplatin)
• CEPP (Cytoxan + etoposide [VP-16] + procarbazine + prednisone).
• Because secondary chemotherapy has generally failed to provide a cure, many patients under age 55 have been
  given high-dose chemotherapy alone or with radiation followed by a bone marrow transplant with moderate
  success (approximately 20 percent long-term disease-free survival). An international clinical trial is testing the
  benefit of autologous marrow transplant compared with secondary chemotherapy.

High-Grade Lymphomas 
Lymphoblastic Lymphoma 
Standard Treatment  Multi-agent chemotherapy, primarily with Cytoxan , Adriamycin , Oncovin and prednisone, is given together with central nervous system prophylactic therapy.
    Patients with extensive disease—usually Stage IV on the basis of bone marrow and/or central nervous system involvement—and a high serum lactate dehydrogenase (LDH) have generally done poorly with conventional